Determination of the appropriate sample size is a crucial part of study design. A sample size must be chosen correctly to allow a study to arrive at valid conclusions. A study that is too small may produce inconclusive results, while a study that is too large will waste scarce resources.
In this white paper we will outline the 5 stage process for determining appropriate power or sample size for clinical trials.
Step 1: Formulate the Study
Before any calculation is conducted, you need to ask yourself a series of questions about the type of analysis you are planning to conduct and therefore what statistical method is most appropriate for your particular study. For exampl