Sample Size Expert Blog

New FDA Guidance on Seamless Clinical Trials

The FDA recently published draft guidance regarding seamless trials that it believes will help accelerate drug development without compromising patient safety in the area of oncology. Below is a quick summary of this guidance.

Topics: sample size challenges Power & Sample Size sample size determination Seamless Trials

The 5 Essential Steps for Sample Size Determination (Webinar)

Re-watch our popular webinar where we list the The 5 Essential Steps for Sample Size Determination. At each step, Eimear will highlight the important function it plays and how to avoid the errors that will negatively impact your sample size determination and therefore your study.

Topics: sample size challenges how to calculate sample size Power & Sample Size Effect Size sample size determination webinar

Top 10 Corporate Clinical Trial Sponsors of 2016

Following on from our previous blog post, The Most Popular Clinical Trial Drugs of 2016, we thought it would be a good idea to take a closer look at the Top 10 Corporate Clinical Trial Sponsors of 2016.

In this post, we explore these Top 10 companies, looking at their developmental histories as well as the drugs they have developed and the number of subjects required for their 2016 registered trials.

Topics: Power & Sample Size Clinical Trials Clinical Trial Sponsors Top10

Wider Integration of Cost Considerations in Sample Size

In part 3/3 of this mini series, Head of Statistics at Statsols - Ronan Fitzpatrick - examines key trends in sample size determination which are being felt in trial design.

Topics: Power & Sample Size integration cost consideration,

The Effect of Adaptive Trials and Sample Size Re-estimation

In part 2/3 of this mini series, Head of Statistics at Statsols - Ronan Fitzpatrick - examines key trends in sample size determination which are being felt in trial design.

Topics: Power & Sample Size adaptive trials sample size restimation

Integrating Uncertainty in Parameter Estimates

In part 1/3 of this mini series, Head of Statistics at Statsols - Ronan Fitzpatrick - examines key trends in sample size determination which are being felt in trial design.

Topics: Power & Sample Size Parameter Estimates

Most Popular Clinical Trial Drugs of 2016

Currently there are over 205,000 registered clinical trials underway throughout the globe. In 2016 over 14,000 new trials were initiated and we thought it would be useful to look at the top drugs under investigation for the year just past.

Topics: Phase III Failure Power & Sample Size

15 Ways to Reduce Sample Size In Clinical Trials

How do you reduce sample size in clinical trials? Reducing sample size without losing power can be accomplished in one of three principles. This paper examines these methods and demonstrates 15 ways to reduce sample size in clinical trials.

Topics: Power & Sample Size Reduce Sample Size Clinical Trials

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