Sample Size Expert Blog

15 Ways to Reduce Sample Size In Clinical Trials

How do you reduce sample size in clinical trials? Reducing sample size without losing power can be accomplished by one of three principles. This paper examines these methods and demonstrates 15 ways to reduce sample size in clinical trials.

Topics: Power & Sample Size Reduce Sample Size Clinical Trials

A Brief Overview of Bayesian Analysis for Biostatisticians

Bayesian methods are becoming more common in clinical trials. Previously, a lack of computing in sample size software hindered the use of these methods, but improvements in the area have led to more widespread use. To examine what’s new and different about Bayesian sample size determination, we first need to consider what’s done in a traditional setting.

Topics: Bayesian Assurance Reduce Sample Size nQuery Bayes Continual Reassessment Method (CRM) Dose Escalation Introduction to Sample Size

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