Sample Size Expert Blog

The 5 Essential Steps for Sample Size Determination (Webinar)

Re-watch our popular webinar where we list the The 5 Essential Steps for Sample Size Determination. At each step, Eimear will highlight the important function it plays and how to avoid the errors that will negatively impact your sample size determination and therefore your study.

Topics: Power & Sample Size sample size determination webinar sample size challenges Effect Size how to calculate sample size

Practical Methods to Overcome Sample Size Challenges (Webinar)

Re-watch our popular webinar where we examine some of the most common and practical challenges you will experience while calculating sample size for your study. These challenges are split into two categories: 1. Overcoming Sample Size Calculation Challenges (Survival Analysis Example) & 2. Overcoming Study Design Challenges (Vaccine Efficacy Example).

Topics: Bayesian Assurance sample size determination webinar Case-Control Analysis Alternative Randomization Methods sample size challenges Effect Size Drop Out Rare Events

A Brief Overview of Bayesian Analysis for Biostatisticians

Bayesian methods are becoming more common in clinical trials. Previously, a lack of computing in sample size software hindered the use of these methods, but improvements in the area have led to more widespread use. To examine what’s new and different about Bayesian sample size determination, we first need to consider what’s done in a traditional setting.

Topics: Introduction to Sample Size Reduce Sample Size Bayesian Assurance nQuery Bayes Dose Escalation Continual Reassessment Method (CRM)

5 Reasons Why Pharma Companies Are Calculating Bayesian Assurance

The pharmaceutical industry is increasingly turning to Bayesian methods in an attempt to improve efficiency and enhance decision making. Assurance (Bayesian Power) is becoming a key feature of these Bayesian methods. This is not to replace traditional power but to complement it.

Topics: Clinical Trials Bayesian Assurance nQuery Bayes sample size determination

Dose Escalation: Quickly determine the Maximum-Tolerated Dose through Continual Reassessment Method

A key drawback of the traditional 3+3 design in dose escalation is its slow processing of data to reach the target dose. In contrast, the Continual Reassessment Method designs produce an expedited convergence to the target dose or the doses near target.

Topics: Clinical Trials Dose Escalation Continual Reassessment Method (CRM)

Why Frequentists are using Bayesian Statistics in Clinical Trial Design

Statisticians are familiar with the long standing debate regarding Frequentists Vs Bayesian methodologies and the benefits (or negatives) that each present to a particular situation. However, we are now experiencing a rise in traditional frequentists using Bayesian statistics. What are the reasons behind this? While complex, we can identify two high level points.

Topics: Clinical Trials Bayesian Assurance nQuery Bayes

Top 10 Corporate Clinical Trial Sponsors of 2016

Following on from our previous blog post, The Most Popular Clinical Trial Drugs of 2016, we thought it would be a good idea to take a closer look at the Top 10 Corporate Clinical Trial Sponsors of 2016.

In this post, we explore these Top 10 companies, looking at their developmental histories as well as the drugs they have developed and the number of subjects required for their 2016 registered trials.

Topics: Power & Sample Size Clinical Trials Clinical Trial Sponsors Top10

Wider Integration of Cost Considerations in Sample Size

In part 3/3 of this mini series, Head of Statistics at Statsols - Ronan Fitzpatrick - examines key trends in sample size determination which are being felt in trial design.

Topics: Power & Sample Size cost consideration, integration