Sample Size Expert Blog

Most Popular Clinical Trial Drugs of 2016

Currently there are over 205,000 registered clinical trials underway throughout the globe. In 2016 over 14,000 new trials were initiated and we thought it would be useful to look at the top drugs under investigation for the year just past.

Topics: Power & Sample Size Phase III Failure

15 Ways to Reduce Sample Size In Clinical Trials

How do you reduce sample size in clinical trials? Reducing sample size without losing power can be accomplished in one of three principles. This paper examines these methods and demonstrates 15 ways to reduce sample size in clinical trials.

Topics: Power & Sample Size Clinical Trials Reduce Sample Size

Why do phase III clinical trials fail?

Why do Phase III clinical trials fail and how can we improve them? Dr. Grignolo, PhD, Corporate Vice President of PAREXEL International, the multinational life sciences consulting firm, recently examined this issue in a paper titled: Phase III Trial Failures: Costly, But Preventable.

We have reviewed this journal and brought you the primary findings as they appeared in Applied Clinical Trials Volume 25, Issue 8 and also on appliedclinicaltrialsonline.com.

Topics: Power & Sample Size Phase III Failure

What is the difference between Superiority vs. Equivalence vs. Non-inferiority in clinical trial design

The terms superiority, equivalence and non-inferiority are used frequently in publications on clinical trials. To someone starting out in clinical research these three terms and their precise meaning can be quite difficult to grasp. Indeed even experienced researchers have trouble getting their head around these hypotheses. So, what do these terms mean?

Topics: Introduction to Sample Size Clinical Trials nQuery

Making it personal: N-of-1 trials, allowing for individuality but not overdoing it

N-of-1 trials are the application of the machinery of randomised clinical trials to the individual patient. Episodes of treatment rather than individual patients become the fundamental unit of inference and patients are repeatedly randomised to an experimental and a control treatment (say) in order to establish the effect of treatment. Popular designs involve cycles of episodes of treatment with the patient being assigned to a random order within cycles. (Continued below)

Topics: Power & Sample Size Clinical Trials N-of-1 Trials Stephen Senn

Predictive Analytics: From Proverbs to PX

The concept of Predictive Analytics is nothing new. The basic idea of using the past to predict the future is in fact very old. Many old phrases we still use today is an example of predictive analytics in very simple forms. If you ever heard the phrase ”Red sky at night, sailors delight” then you will realise sailors have been already using predictive analytics for the longest time.

Topics: PX Analytics Predictive Analytics

How the "sexiest job of the 21st century" will be automated by 2025

Before I tell you how experts are predicting that the sexiest job of the 21st century is going to be automated by 2025, have a guess what it is? You may be surprised to learn it is not the traditional jobs we may think that are top of the list, such as lawyers, pilots, doctors or stockbrokers.

Topics: PX Analytics Automation

Intact social cognitive processes in outpatients with anorexia nervosa: a pilot study

nQuery Sample Size Calculator has been featured in another interesting study.

The aim of this article "was to assess social cognition in community patients suffering from anorexia nervosa (AN) compared to healthy controls".

Anorexia  nervosa — often simply called anorexia — is an eating disorder with an intense fear of gaining weight. People with anorexia go to extreme lengths in order to avoid gaining weight. This has a huge impact on them both physically and mentally.  

Below is an abstract from the article

The research hypothesis indicated that patients suffering from anorexia represent no significant difference in social cognitive functioning in comparison to the healthy controls. These assessment scales were used to identify whether there are any problems according to social cognitive functioning especially emotion recognition and theory of mind (ToM). The primary outcome assessment was to identify social cognitive deficits in anorexic outpatients and secondary outcome was to verify whether these problems in emotional functioning found in women in acute phase of AN are state or trait effects. Full Article

Topics: nQuery Publications Citing nQuery Sample Size Calculator